The biological behavior of invasive cervical cancer, a leading cause of cancer related deaths in women is not always predictable. Even when the disease is localized to the cervix, 15-20% patients have recurrences. The present study is designed as a multi-centric one with 4 leading centers-ACTREC/TMC (Navi-Mumbai), ICPO (Noida), NCBS (Bangalore) and RGCB (thiruvananthapuram), to analyze the expression of select markers, which have been shown in isolated studies to be of relevance in the HPV mediated cervical carcinogenesis.