Clinician

RESEARCH

Our laboratory aims at incorporating a systematic approach to bioanalysis, preclinical and clinical research guided by standard operating procedures and good clinical and laboratory practices so as to achieve the highest level of efficiency, accuracy and reproducibility in our pursuit of excellence in clinical pharmacology and experimental therapeutics (bedside-to-bench pharmacology). We aim to become a centre of excellence for research, training and services in clinical pharmacology and experimental therapeutics encompassing a range of activities including but not limited to drug development, personalized medicine, pharmacovigilance and pharmacoeconomics.

Phase 1 unit: The department has an active phase-1 unit to foster pharmacokinetic, pharmacogenetic, BA/BE and first-in-human clinical trials. The 2 bedded ward is a specialized unit capable of providing round the clock care and supervision to the study participants under the stewardship of an excellent team of study investigators, medical oncology and nursing staff.

Bioanalytical unit: The department has a dedicated bioanalytical unit with high resolution Q Trap LC-MS/MS systems, UPLC RS-3000 Model Dionex and HPLC JASCO with absorbance, fluorescence detector. The division is led by a technical team with a vast experience in development, validation and analysis of preclinical and clinical biological matrices. They also form an integral part of ongoing therapeutic drug monitoring services, toxicokinetic, metabolic profiling and BA/BE clinical trials in the department.

Preclinical research: The department is actively involved in developing therapeutic interventions for various cancers as well as the mitigation of serious adverse effects associated with cancer treatment. This includes development of radioprotectors and drugs for the prevention of morbidities associated with bone marrow transplantation such as graft versus host disease (GvHD). The pharmacokinetics and efficacy of drugs in special situations such as malnutrition are also being investigated. The lab undertakes end-to-end non-clinical investigations including pharmacokinetics and biodistribution, toxicity, efficacy and mechanistic studies.